I'm currently based in Houston... but I'm on a 4 day trip... and haven't seen houston again since Day 1. My flying has been all aroung the US in and out of the other bases.
Overall... there's the standards... like Houston crews see more Mexico and Red-eye/LAX flying... Newark crews see more Canada & Newfoudland flying etc... However, it's certainly not uncommon for anyone from any base to fly to any of the destinations in the COEX system.
Regardless, I've been here shy of 3 years... and I've yet to hit every destination in the system, and quite frankly don't know of anyone personally who has. We have a lot of desitinations...
It's all luck of the draw... how the lines are built... and where, if you're on reserve, scheduling sends you.
Bob